Français
Deutsch
Español
Italiano
Português
日本語
한국어
Русский
Central Electricity Regulator Issues Staff Paper On Power Market Coupling
Aug 31, 2023Liquid Sulfur Silane Coupling Agent Market Size, Demand, Share, Revenue, Key Players, Growth, and Forecast 2031
Aug 23, 2023Lessons learned: A breakaway coupling becomes a dropped object
Aug 19, 2023Stainless Steel Elastic Coupling Market Global Development Analysis 2023 to 2029
Aug 22, 2023Electric Power Steering Market 2023 Technology Advancements and Research
Aug 08, 2023Enhanced Ventricular-Arterial Coupling With S/V Therapy
Jun 29, 2025Photo Credit: iStock.com/Nerthuz
Improved heart function with sacubitril/valsartan was linked to enhanced ventricular-arterial coupling and cardiac efficiency in individuals with reduced ejection fraction.
A study published in June 2025 issue of American Journal of Cardiology described left ventricular (LV) reverse remodeling (RR) as a known response to therapies that alleviate neurohormonal activation and hemodynamic overload in individuals with heart failure with reduced ejection fraction (HFrEF).
Researchers conducted a retrospective study to analyze whether LVRR with sacubitril/valsartan (S/V) treatment was associated with changes in VA coupling and alterations in mechanoenergetic parameters.
They analyzed data from 662 individuals with HFrEF and LV ejection fraction (LVEF) ≤40% who received S/V therapy across multiple centers. The mean age was 65±11 years. Non-invasive pressure-volume (PV) loops were derived using echocardiography and brachial artery blood pressure. Arterial elastance (Ea), LV elastance (Ees), and the Ea/Ees ratio were calculated. Mechanoenergetic parameters, including stroke work, potential energy (PE), PV area (PVA), and LV efficiency, were also estimated.
The results showed that at a median follow-up of 7.8 months, 14% of individuals demonstrated LVRR, defined as a LVEF increase >10% and a relative reduction in LV end-systolic volume >15%. In this subgroup, VA coupling improved from 2.90 ± 1.33 to 1.58 ± 0.53 (−45%) and LV efficiency rose from 46% to 57% (+24%). The PE declined from 0.68 ± 0.18 joule to 0.44 ± 1.0 joule (−35%). VA coupling showed strong inverse correlations with LV efficiency at baseline (r = −0.92) and at follow-up (r = −0.74).
Investigators concluded that individuals with LVRR and treated with S/V were linked to improved VA coupling, which likely contributed to enhanced LV efficiency as reflected by the SW to PVA ratio.
Source: ajconline.org/article/S0002-9149(25)00372-8/abstract
View all posts